U.S. Food and Drug Administration Approves Loncastuximab Tesirine-lpyl for Large B-cell Lymphoma

On April 23, 2021, the U.S. Food and Drug Administration (FDA) announced it has approved loncastuximab tesirine-lpyl (ZYNLONTA, ADC Therapeutics), a CD-19-directed antibody and alkylation agent conjugate, for adult patients with relapsed or refractory large B-cell lymphoma after two or more lines of systemic therapy, including diffuse large B-cell lymphoma (DLBCL) not otherwise specified, DLBCL arising from low grade lymphoma, and high-grade B-cell lymphoma.  This is the first and only CD-19-targeted antibody drug conjugate as a single agent for relapsed/refractory DLBCL.

“Diffuse large B-cell lymphoma is the most common type of lymphoma, however, relapsed or refractory disease remains a significant area of unmet need,” said Meghan Gutierrez, Chief Executive Officer of the Lymphoma Research Foundation. “The approval of loncastuximab tesrine-lpyl offers patients a new treatment option and new hope for improving outcomes.”

For more information on the FDA approval of loncastuximab tesirine-lpyl (ZYNLONTA), visit the FDA’s website FDA’s website.  To learn more about treatment options for DLBCL, visit the DLBCL Learning Center.

Virtual Ask the Doctor Program: Chemoimmunotherapy

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Ubaldo E. Martinez-Outschoorn, MD
Jefferson Health

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