Researcher Spotlight: Tomohiro Aoki, MD, PHD BC CANCER Interactions between tumor cells and healthy cells leads to the formation of a tumor microenvironment that can affect response to treatment. These relationships are bidirectional: Pressure from healthy immune cells can lead…
Researcher Spotlight: BOYU HU, MD The University of Utah Some patients with chronic lymphocytic leukemia (CLL) respond poorly to treatment due to genetic changes that affect primary DNA damage repair (DDR) mechanisms targeted by currently approved agents. Instead, the CLL…
Researcher Spotlight: Lorenzo Falchi, MD MEMORIAL SLOAN KETTERING CANCER CENTER For the last two decades, follicular lymphoma (FL) has been treated with traditional chemotherapy. While effective, this treatment is not considered curative and can cause a host of short- and…
Researcher Spotlight: Zachary Epstein-Peterson, MD MEMORIAL SLOAN KETTERING CANCER CENTER Peripheral T-cell lymphomas are a rare and challenging group of malignancies to treat. Mutations in the isocitrate dehydrogenase 2 (IDH2) enzyme have been identified in a subgroup of patients with…
Researcher Spotlight: Juan Alderuccio, MD MILLER SCHOOL OF MEDICINE OF THE UNIVERSITY OF MIAMI Relapsed or refractory follicular lymphoma (FL) is considered an incurable lymphoma malignancy, with most patients needing lifelong treatment. Loncastuximab tesirine is an antibody-drug conjugate that targets…
Researcher Spotlight: Niloufer Khan, MD, MS Memorial Sloan Kettering Cancer Center Cutaneous T-cell lymphoma (CTCL) is a type of skin lymphoma usually managed as a chronic disease without a standard frontline therapy, and treatment plans typically vary from patient to patient.…
Researcher Spotlight: Brian Sworder, MD, PhD Stanford University School of Medicine Chimeric antigen receptor (CAR) T cells have shown to be incredibly beneficial for patients with lymphomawho have relapsed after chemotherapy. Unfortunately, however, several patients will still go on to relapse after…
Researcher Spotlight: Patrizia Mondello, MD, PhD Mayo Clinic, Rochester Follicular lymphoma (FL) is generally slow-growing cancerwith an overall favorable prognosis. One subset, known asFL3B, has a distinctly worse clinical outcome with limited treatment options. The same treatments used to manage the other,…
Researcher Spotlight: Coraline Mlynarczyk, PhD Joan & Sanford I. Weill Medical College of Cornell University Diffuse Large B Cell Lymphoma (DLBCL) is a heterogenous B-cell malignancy, with each patient presenting with a heavy and diverse burden of alterations in their DNA. Therefore,…
Researcher Spotlight: Zachary Epstein-Peterson, MD Memorial Sloan Kettering Cancer Center In recent years, several new therapies have been investigated for treating T-cell lymphomas. Some of thesemedicines work in up to 50 percent of patients whoselymphoma has relapsed or has not responded to…